A model of the adult human atrial cell

We have developed a mathematical model of the electrophysiological responses in a single cell from the adult, human atrium, based on action potential and voltage clamp data recorded at 33/spl deg/C. Our formulation consists of two closely interacting parts a Hodgkin-Huxley (HH) membrane equivalent circuit model for the sarcolemma, and a fluid compartment model for the intracellular medium. These simulations produce acceptable fits to experimentally recorded action potential data, and can therefore be used to gain insight into how the ionic currents interact during the action potential in human atrial cells.