A High-order Cross-cumulant Coefficient measure for registering medical image or its sequence

A novel measure, called as the Normalized High-order Cross-cumulant Coefficient (NHCC), for registering medical images or its sequence is proposed in this paper. The analytical results show that the proposed NHCC cannot only easily capture the correlation information among the multiple variables simultaneously, but also suppress the additive Gaussian noise influence on the registration results of the image or its sequence. Simulation results verify the effectiveness of the proposed measure.