Effects of iron oxide magnetic nanoparticles on osteoblast proliferation

Iron oxide nanoparticles are promising candidates for drug delivery systems to treat osteoporosis due to their biocompatibility and magnetic properties. Magnetite and maghemite nanoparticles were synthesized here using a co-precipitation method. The particles were characterized by transmission electron microscopy (TEM). Effects of CaP coating iron oxide magnetic nanoparticles on the proliferation of osteoblasts (OB) were determined after 1, 3 and 5 days of culture. The correlation of iron oxide nanoparticle concentration on OB density was also investigated.