Recognition Essential Protein Based on Multi Parameters Combination

For the low recognition degree of essential protein based on topological parameter, the correlation between the essentiality of proteins and their main topological parameters is analyzed and the nature of the essentiality-judgment ability of the parameters is explored firstly. Then, the mutual information of essential node these parameters contain is brought out in virtue of their correlation, based on which the construction method of combined parameter is put forwards. In deeper study, the recognition degree of a combined parameter is found to have close relations not only to the performances of the independent parameters it constructed from, but also to the correlation between these independent parameters, and a asynchronous algorithm based on parameters combination is proposed lastly. The results of the emulation are not only consistent to each other highly, but also show that the performance of the method is better than that of the others obviously.