Simulating ECG changes during acute myocardial ischemia

In this paper the changes in ECG waveforms during the first 20 minutes of an ischemic event are studied in a simulation model. A new method, based on the shortest path algorithm, is introduced for simulating the effects of the reduced propagation velocity within an ischemic zone on the timing of the depolarization sequence throughout the entire myocardium and the resulting ECG changes.