A Precise and Automatic Gridding Approach to Noise-Affected and Distorted Microarray Images

In this paper, a precise and fully-automatic approach to the determination of the grid alignment (Gridding) on microarray images is presented. The proposed approach is compared to state-of-the-art software programs and techniques. The conducted experiments demonstrate that it is very effective even when it is applied to noisy or distorted images as well as to images containing spots with various intensities.