Small-World Network Approach to Identify Nucleus Residues of the B1 Domain of Protein G#

The B1 domain of protein G is a paradigm for kinetics studies. In this work, the protein structure of GB1 is modeled as an unweighted amino acid network. We find that the unweighted amino acid network is the typical property of small-world network. The nucleus residues of GB1 are identified by the analysis of the network parameter: betweenness. The results are consistent with the previous experimental and theoretical studies.