Influence of Formaldehyde on the Expression of Rab26 Gene in HEK293 Cell in Vitro

In this study HEK293 cell was treated with HCHO (ges 250 mu M) of different concentrations and Rab26 gene expression was examined by using RT-PCR method. The results showed that with the elevation of the concentrations of HCHO, the amount of DNA-protein crosslink (DPC) was significantly enhanced (P< 0.01). Meanwhile, accompanied with the elevation of DPC amount after HCHO treatment, the amount of replication and transcription of Rab26 was reduced as examined by PCR and RT-PCR method.