Optimal design of scan intervals for glucose kinetic modeling using dynamic imaging data from PET

In tracer kinetic modeling with positron emission tomography (PET) it is required to take the tracer tissue time-activity images which are of accumulated counts corresponding to the scan intervals. In this paper, the optimal design of the scan intervals to estimate metabolic rate of glucose (MRGlc) is investigated. Specific features of the PET measurements are considered. The results show that, if the scan intervals are selected properly, the number of dynamic images required can be reduced by approximately 75%, the time for data analysis can be reduced, and the accuracy of parameter estimation can be improved.<
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