Bioluminescent bioreporter integrated circuit sensors for very low-level chemical detection

An integrated CMOS microluminometer for detection of very low-level bioluminescence is presented. Signal processing is accomplished with a current-to-frequency converter circuit. Photodiode, integrator, voltage reference circuit and noise are analyzed in detail in this paper. The biosensor chip was fabricated using a standard 0.35mum CMOS process and dissipate 3 mW for 3.3 V power supply. Test results are given to prove the concept