Factor analysis of dynamic structures (FADS) for quantitative modelling of positron emission tomographic (PET) image sequences

Summary form only given, as follows. From positron emission tomography (PET) image sequences it is possible to estimate biological parameters by means of measurements inside regions of interest. Several compartments, with various contributions, are present in each region. FADS automatically provides factors (kinetics corresponding to a pure compartment), factor images (spatial distribution of the factor), and their respective contributions. Using three radioisotopes with different decay time constants to simulate biological kinetics, mixed in various proportions in several vials, the authors validated FADS for (1) the number of kinetics and the expected time constants, (2) the spatial distribution of the compartments, and (3) the percentage of isotopes in each vial.<
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