Measurement of acetylcholine receptor function in microcircuit-coupled myoblasts

An electrophysiological measurement principle for long-term, noninvasive monitoring of the nicotinic acetylcholine receptor function is described. The measurement is based on the ability to record agonist-induced depolarizations of clonal myoblasts that have formed high impedance seals with extracellular microcircuit electrodes. The technique appears promising for several types of assays and environmental monitoring applications.<
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