A MEMS based Optical Coherence Tomography Imaging System and Optical Biopsy Probes for Real-Time, High Resolution In-Vivo and In-Vitro 2-D or 3-D Imaging

A fully-functional, real-time optical coherence tomography (OCT) system based on a high-speed, gimbal-less micromachined scanning mirror is presented. The designed MEMS control architecture allows the MEMS based imaging probes to be connected to a time-domain, a Fourier domain or a spectral domain OCT system. Furthermore, a variety of probes optimized for specific laboratory or clinical applications including various minimally invasive endoscopic, handheld or lab-bench mounted probes may be switched between effortlessly and important driving parameters adjusted in real-time. In addition, artifact free imaging speeds of 33 mus per voxel have been achieved while imaging a 1.4 mmtimes1.4 mmtimes1.4 mm region with 5 mumtimes5 mumtimes5 mum sampling resolution (SD-OCT system)