Theoretical assessment of FePt nanoparticles as heating elements for magnetic hyperthermia

FePt magnetic nanoparticles (MNPs) are expected to be a high-performance nanoheater for magnetic hyperthermia because of their high Curie temperature, high saturation magnetization, and high chemical stability. Here, we present a theoretical performance assessment of chemically disordered fcc-phase FePt MNPs. We calculate heat generation and heat transfer in the tissue when an MNP-loaded tumor is placed on an external alternating magnetic field. For comparison, we estimate the performances of magnetite, maghemite, FeCo, and L1/sub 0/-phase FePt MNPs. We find that an fcc FePt MNP has a superior ability in magnetic hyperthermia.