The virtual physiological human: challenges and opportunities

This paper summarises the current achievements and future developments of the virtual physiological human (VPH) technology. The VPH is an organised collection of computational frameworks and ICT-based tools for the multilevel modelling and simulation of the human anatomy and physiology. Once sufficiently developed, the VPH will provide an essential technological infrastructure to the Physiome Project, to pathology-specific initiatives in translational research, and to vertical solutions for the biomedical industry