Nanoscale system design challenges: Business as usual?

While process technologists are obsessed to pursue Moore's curve down to nanoscale dimensions, design technologists are confronted with gigascale complexity. On the other hand, post-PC products require zero cost, zero energy yet software programmable novel system architectures to be sold in huge volumes and be designed in exponentially decreasing time. How do we cope with these novel silicon architectures? What challenges in research does this create? How to create the necessary tools and skills and how to organise research and education in a world driven by shareholders value?