Myocardial blood flow by PET: correction for spillover and partial volume

A method, based on the a bolus H/sub 2//sup 15/O blood flow measurement, which can correct for spillover and partial volume in position emission tomography (PET) is presented. The results of this method are compared, at least partially, to other methods, in particular the radiolabeled carbon monoxide method for predicting spillover and the use of high spatial resolution gated cardiac magnetic resonance imaging scans to predict partial volume (PV). The PV and spillover corrections derived from the /sup 15/O-water results can be used to correct for PV effects and spillover effects in the myocardial activity distribution of any other positron emitting isotope, for example /sup 18/F-deoxyglucose.<
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