Cell death mechanism in human epidermoid carcinoma A431 cells triggered by photodynamic therapy with Photofrin/sup /spl reg//

Photofrin/sup /spl reg// distributes dynamically in A431 cells; the plasma membranes and Golgi complex are the main target sites of Photofrin/sup /spl reg// after a brief (3 h) and prolonged (24 h) incubation, respectively. Cells with differentially localized Photofrin/sup /spl reg// displayed distinct death phenotypes in response to PDT.