Drug dosing control in clinical pharmacology

In this paper, the potential applications of control technology to clinical pharmacology are discussed, specifically the control of drug dosing. The use of closed-loop control for clinical pharmacology can significantly advance the understanding of the effects of pharmacological agents and anesthetics, as well as advance the state-of-the-art in drug delivery systems. In addition to delivering sedation to critically ill patients in an acute care environment, potential applications of closed-loop control include glucose, heart rate, and blood pressure regulation.