Robust deconvolution of high-frequency ultrasound images using higher-order spectral analysis and wavelets

Deconvolution of high-frequency (30-40 MHz) ultrasonic images of human skin was studied in vivo. Separate one-dimensional (1-D) functions for the axial and lateral profiles were first estimated using higher-order spectral methods. Subsequently, deconvolution was implemented using a regularized inverse Wiener filtering of the wavelet and scaling coefficients that were obtained after a wavelet decomposition of the RF signals. Deconvolution was first performed in the axial direction, then in the lateral direction. The methods were applied to data obtained from the skin of 16 volunteers using three different transducers. Significant improvements in both the axial and lateral resolutions were obtained in all the cases. Features such as hair follicles in the dermis and fingerprints on the surface of the finger were more clearly displayed in the processed images compared to the original images. The results indicate that the deconvolution method using higher-order spectral methods and wavelet analysis could significantly improve the quality of high-frequency ultrasonic skin images.