Wet-Neuromorphic Computing: A New Paradigm for Biological Artificial Intelligence

As we delve into a life governed by artificial intelligence (AI), ongoing research continues to discover new forms of intelligence that are efficient and closely mimic an organism’s brain in terms of performance. This article presents a new concept termed wet-neuromorphic computing, in which biological cells or organisms are leveraged to perform computational tasks using their natural molecular functions. We map key neuromorphic properties to natural biological computing observed in bacteria, 3-D organoids, and Caenorhabditis elegans. To expand beyond the inspiration of the brain to create conventional neuromorphic computing, the study presents a case study that demonstrates bacterial AI computing using the gene regulatory neural network derived from Escherichia coli’s gene regulatory network for pattern recognition, validated through wet lab experiments. Finally, challenges and future directions are discussed.