Glucosim: a simulator for education on the dynamics of diabetes mellitus

Glucose-insulin interactions in healthy and insulin-dependent diabetic humans are simulated using an overall and a detailed model based on pharmacokinetic diagrams of insulin and glucose. Both models are capable of predicting blood glucose and insulin levels, total glucose uptake and renal glucose excretion. The simulator is integrated with a graphical user interface to provide a user-friendly environment for performing virtual experiments with various characteristics, diet and exercise conditions.