A flexible microcantilever aptasensor for trace level detection of ricin | IEEE Conference Publication | IEEE Xplore

A flexible microcantilever aptasensor for trace level detection of ricin


Abstract:

This work introduces a flexible piezoresistive microcantilever by using polyimide (PI) and silicon oxide (SiO2) as the insulation layers of titanium (Ti) strain resistors...Show More

Abstract:

This work introduces a flexible piezoresistive microcantilever by using polyimide (PI) and silicon oxide (SiO2) as the insulation layers of titanium (Ti) strain resistors. The microcantilever is elaborately devised including the strain and piezoresistive characteristics of Ti and the film formation and patterned process of the PI. The fabricated PI/Ti/SiO2 microcantilever is steady and flexible with less than 3 μV@3V output voltage fluctuation in PBS buffer environment and a spring constant of 21.28 nN/μm. An aptasensor is developed through functionalizing the microcantilevers, which is able to detect ricin of 10 ng/mL concentration with good specificity. All the experiment results show that the PI/Ti/SiO2 microcantilever-based aptasensor enables label free and high sensitivity chemical/biological molecules detection and analysis.
Date of Conference: 18-22 June 2017
Date Added to IEEE Xplore: 27 July 2017
ISBN Information:
Electronic ISSN: 2167-0021
Conference Location: Kaohsiung, Taiwan

References

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