Photocurable PUA (Poly Urethaneacrylat) cantilever integrated with ultra-high sensitive crack-based sensor

This paper describes the fabrication and characterization of ultra-high sensitive polymer cantilever to precisely monitor the change in contraction force of cardiomyocytes. The mechanical crack-based sensor inspired from a spider showed enhanced sensitivity towards strain and vibration in nature. In spite of all these interesting characteristics, the crack-based sensor has not yet been used for biomedical applications such as detecting a small force generated from cells. Herein we made successful attempt to develop a novel sensing technique for measuring the contraction force of cardiomyocytes. This idea can be applied for the development of cantilever-based cardiac toxicity screening systems.