Parallel microarraying of microfluidic droplets for high-throughput integration with matrix-assisted laser desorption ionization mass spectrometry

Droplet microfluidics affords researchers the ability to rapidly generate discretized conditions at kHz rates cheaply and controllably. We leveraged a simple microwell array to enable a parallel process of droplet microarraying, droplet sample deposition through surfactant removal, and thermally actuated device disassembly for facile integration with MALDI mass spectrometry analysis.