Multi-modal impedance spectroscopy device for simultaneous measurement of electrical and mechanical properties of cells

We demonstrate a novel microfluidic device based on electrical impedance spectroscopy (EIS) which independently measures the electrical properties of cells and simultaneously estimates their mechanical properties by measuring transit times across a mechanical constriction. The device also allows electrically probing the effect of mechanical squeezing on the cell. Compared to conventional EIS techniques that measures the electrical impedance of cells solely across a constriction, the proposed technique offers more versatility and enables multi-modal analysis of cellular properties.