Plasmonic-electrochemical dual modality microfluidic sensor for cancer biomarker detection

A dual-modality microfluidic immunosensor is reported for the detection of cancer biomarker proteins using graphene oxide assembled periodic gold nanoposts array. The sensor uniquely provides both electrochemical and surface plasmon resonance (SPR) signatures on a single platform. Sensitivities for both electrochemical and SPR detection schemes are found to be 3.94 μA/μM/cm² in a range of 1×10^-15 M to 0.1×10^-6M, and 2.9 nm/μM/cm² in a range of 1×10^-15 M to 1×10^-9M, respectively, for the detection of epidermal growth factor receptor 2 (ErbB2) breast biomarker. The present dual-modality sensor approach enables improved detection reliability and precision, and reduced false reads.