Corneal deformation dynamics in normal and glaucoma patients utilizing scheimpflug imaging

The purpose of this study was to explore the corneal deformation dynamics recorded in raw Scheimpflug images of CorVis ST tonometer to evaluate age- and glaucoma-related changes in corneal biomechanics. This was a prospective study in which 18 subjects were recruited and divided into three equal groups (healthy young, healthy older and older glaucoma group). Up to three measurements by CorVis ST tonometer were acquired on the left eye of each subject. Raw Scheimpflug images of CorVis ST were used to extract changes in anterior and posterior corneal profiles, which were further modeled by a Chebyshev polynomial expansion of optimally determined order. Corneal deformation dynamics were studied via time-varying series of Chebyshev polynomial coefficients, in which three phases of corneal deformation were determined. The first and the last phase of corneal dynamics were fitted with bilinear functions. Further, the slope of each linear trend in the model was tested between the groups. Statistically significant differences were observed in the final return phase of corneal dynamics between the older group of subjects and those of glaucoma subjects indicating possible biomechanical differences in their tissues that could only be observed with minimum applied pressure.