Modeling studies of cellular response to ultrashort, high-intensity electric fields
Joshi, R.P.; Hu, Q.; Schoenbach, K.H.; Lakdawala, V.K.
Electrical Insulation and Dielectric Phenomena, 2003. Annual Report. Conference on
Volume , Issue , 19-22 Oct. 2003 Page(s): 357 - 360
Digital Object Identifier  
Summary: The dynamics of electroporation in biological cells subjected to nanosecond, high intensity pulses are studied based on a coupled scheme involving current continuity and Smoluchowski equations. A new distributed current model is presented for potential distribution to includes dynamic conductivities of cell membranes and substructures caused by pore formation. Different cell responses of normal and malignant (Farage) tonsillar B-cells are compared and discussed. It is shown that ultrashort, high-intensity electric pulses could selectively damage cancer cells.

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