Finding transcription factor binding sites in DNA sequences: a template based approach
Gunewardena, S.; Zhaolei Zhang
Statistical Signal Processing, 2005 IEEE/SP 13th Workshop on
Volume , Issue , 17-20 July 2005 Page(s):990 - 995
Digital Object Identifier   10.1109/SSP.2005.1628739
Summary:The short and highly degenerate nature of transcription factor (TF) binding sites makes their identification a challenging task. We propose a new method based on templates for identifying TF binding sites. Templates account for sequence structure and nucleotide polymorphisms present in TF binding sits providing them with a greater discriminatory capability to methods based on sequence homology

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