Design of a high-resolution, high-sensitivity PET camera for humanbrains and small animals
Moses, W.W.; Virador, P.R.G.; Derenzo, S.E.; Huesman, R.H.; Budinger, T.F.
Nuclear Science, IEEE Transactions on
Volume 44, Issue 4, Aug 1997 Page(s):1487 - 1491
Digital Object Identifier 10.1109/23.632691
Summary:The authors present design parameters for a 3-D PET camera with
high sensitivity (35 cm detector ring diameter, 15 cm axial field of
view) and isotropic high resolution provided by detector modules capable
of depth of interaction (DOI) measurement. Detector modules are made of
LSO crystals (3 mm square by 30 mm deep)-the small module size and short
decay time of LSO reduce the detector dead time by a factor of 14
compared to conventional EGO detector modules and narrow the coincidence
window width to 4 ns. This yields an expected peak noise equivalent
count rate of 800 kcps and noise equivalent sensitivity of 1370
kcps/μCi/cc with a 20 cm diameter phantom-three to five times higher
than conventional scanners. With 5 mm fwhm DOI resolution, the expected
reconstructed spatial resolution is <3.0 mm fwhm throughout the
entire field of view. Depth of interaction measurement information is
incorporated into the reconstruction algorithm by rebinning onto a
regularly spaced grid. Attenuation correction is performed with an
orbiting single transmission source
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