An evaluation of maximum likelihood reconstruction for SPECT
Chornoboy, E.S.; Chen, C.J.; Miller, M.I.; Miller, T.R.; Snyder, D.L.
Medical Imaging, IEEE Transactions on
Volume 9, Issue 1, Mar 1990 Page(s):99 - 110
Digital Object Identifier 10.1109/42.52987
Summary:A reconstruction method for SPECT (single photon emission
computerized tomography) that uses the maximum likelihood (ML) criterion
and an iterative expectation-maximization (EM) algorithm solution is
examined. The method is based on a model that incorporates the physical
effects of photon statistics, nonuniform photon attenuation, and a
camera-dependent point-spread response function. Reconstructions from
simulation experiments are presented which illustrate the ability of the
ML algorithm to correct for attenuation and point-spread. Standard
filtered backprojection method reconstructions, using experimental and
simulated data, are included for reference. Three studies were designed
to focus on the effects of noise and point-spread, on the effect of
nonuniform attenuation, and on the combined effects of all three. The
last study uses a chest phantom and simulates Tl-201 imaging of the
myocardium. A quantitative analysis of the reconstructed images is used
to support the conclusion that the ML algorithm produces reconstructions
that exhibit improved signal-to-noise ratios, improved image resolution,
and image quantifiability
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