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Neural Probes for Concurrent Detection of Neurochemical and Electrophysiological Signals in vivo Johnson, M.D.; Franklin, R.K.; Scott, K.A.; Brown, R.B.; Kipke, D.R. Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the Volume , Issue , 17-18 Jan. 2006 Page(s):7325 - 7328 Digital Object Identifier 10.1109/IEMBS.2005.1616203 Summary:Electrochemical sensing with microelectrode arrays provides a means for monitoring neurotransmitter dynamics across multiple locations within a micro-scale region of brain tissue. Here we present a multi-modal neural probe design for concurrent recording of neurochemical and electrophysiological signals in vivo. Prior to implantation, platinum sites on each array underwent platinum-black electroplating and Nafion electropolymerization, which increased sensitivity to dopamine by 74% and decreased sensitivity to common interferents by at least 89%. In a series of three rats, we applied various electrochemical waveforms to platinum sites and monitored neural activity on adjacent iridium sites. We found that chronoamperometry and constant-potential amperometry did not alter firing rates at +0.25, +0.50, and +0.75 V. In addition, we have demonstrated multi-modal recordings of striatal neurons in response to medial forebrain bundle stimulation » View citation and abstract



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